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1

Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh

Ole Isacson, Hyemyung Seo, Ling Lin, David Albeck, Ann-Charlotte Granholm

Journal:

Trends in Neurosciences

Année:

2002

Langue:

english

Fichier:

PDF, 168 KB

english, 2002

2

Embryonic Stem Cell-Derived Pitx3-Enhanced Green Fluorescent Protein Midbrain Dopamine Neurons Survive Enrichment by Fluorescence-Activated Cell Sorting and Function in an Animal Model of Parkinson's Disease

Eva Hedlund, Jan Pruszak, Thomas Lardaro, Wesley Ludwig, Angel Viñuela, Kwang-Soo Kim, Ole Isacson

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 4.14 MB

english, 2008

3

Blastula-Stage Stem Cells Can Differentiate into Dopaminergic and Serotonergic Neurons after Transplantation

Terrence Deacon, Jonathan Dinsmore, Lauren C. Costantini, Judson Ratliff, Ole Isacson

Journal:

Experimental Neurology

Année:

1998

Langue:

english

Fichier:

PDF, 4.42 MB

english, 1998

4

Context-dependent neuronal differentiation and germ layer induction of Smad4−/− and Cripto−/− embryonic stem cells

Kai-Christian Sonntag, Rabi Simantov, Lars Björklund, Oliver Cooper, Jan Pruszak, Florian Kowalke, Jocelyn Gilmartin, Jixiang Ding, Ya-Ping Hu, Michael M. Shen, Ole Isacson

Journal:

Molecular and Cellular Neuroscience

Année:

2005

Langue:

english

Fichier:

PDF, 1.01 MB

english, 2005

5

Neuroinflammation mediated by IL-1β increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease

James B Koprich, Casper Reske-Nielsen, Prabhakar Mithal, Ole Isacson

Journal:

Journal of Neuroinflammation

Année:

2008

Langue:

english

Fichier:

PDF, 2.04 MB

english, 2008

6

Toward full restoration of synaptic and terminal function of the dopaminergic system in Parkinson's disease by stem cells

Ole Isacson, Lars M. Bjorklund, James M. Schumacher

Journal:

Annals of Neurology

Année:

2003

Langue:

english

Fichier:

PDF, 922 KB

english, 2003

7

Generalized brain and skin proteasome inhibition in Huntington's disease

Hyemyung Seo, Kai-Christian Sonntag, Ole Isacson

Journal:

Annals of Neurology

Année:

2004

Langue:

english

Fichier:

PDF, 1.33 MB

english, 2004

8

Future of cell and gene therapies for Parkinson's disease

Ole Isacson, Jeffrey H. Kordower

Journal:

Annals of Neurology

Année:

2008

Langue:

english

Fichier:

PDF, 146 KB

english, 2008

9

Clinical and preclinical PET correlates of parkinsonism with 11C-WIN 35,428

Journal:

Annals of Neurology

Année:

1994

Langue:

english

Fichier:

PDF, 243 KB

english, 1994

10

In vivo PET Imaging in rat of dopamine terminals reveals functional neural transplants

Anna-Liisa Brownell, Eli Livni, Wendy Galpern, Dr Ole Isacson

Journal:

Annals of Neurology

Année:

1998

Langue:

english

Fichier:

PDF, 809 KB

english, 1998

11

Neuroblast protuberances in the subventricular zone of the regenerative MRL/MpJ mouse

Kasey L. Baker, Stephen B. Daniels, Jessica B. Lennington, Thomas Lardaro, Alexandra Czap, Ryan Q. Notti, Oliver Cooper, Ole Isacson, Salvatore Frasca Jr., Joanne C. Conover

Journal:

The Journal of Comparative Neurology

Année:

2006

Langue:

english

Fichier:

PDF, 1.63 MB

english, 2006

12

Fetal homotypic transplant in the excitotoxically neuron-depleted thalamus: Light microscopy

Marc Peschanski, Ole Isacson

Journal:

The Journal of Comparative Neurology

Année:

1988

Langue:

english

Fichier:

PDF, 2.09 MB

english, 1988

13

Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome

Ann-Charlotte Granholm, Linda Sanders, Hyemyung Seo, Ling Lin, Kerstin Ford, Ole Isacson

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 399 KB

english, 2003

14

Detection of dopaminergic neurotransmitter activity using pharmacologic MRI: Correlation with PET, microdialysis, and behavioral data

Yin Ching I. Chen, Wendy R. Galpern, Anna-Liisa Brownell, Russell T. Matthews, Mikhail Bogdanov, Ole Isacson, John R. Keltner, M. Flint Beal, Bruce R. Rosen, Bruce G. Jenkins

Journal:

Magnetic Resonance in Medicine

Année:

1997

Langue:

english

Fichier:

PDF, 1.48 MB

english, 1997

15

A direct role of the homeodomain proteins Phox2a/2b in noradrenaline neurotransmitter identity determination

Hyemyung Seo, Seok Jong Hong, Su Guo, Hee-Sun Kim, Chun-Hyung Kim, Dong-Youn Hwang, Ole Isacson, Arnon Rosenthal, Kwang-Soo Kim

Journal:

Journal of Neurochemistry

Année:

2002

Langue:

english

Fichier:

PDF, 378 KB

english, 2002

16

Immunophilin ligands can prevent progressive dopaminergic degeneration in animal models of Parkinson's disease

Lauren C. Costantini, Douglas Cole, Pravin Chaturvedi, Ole Isacson

Journal:

European Journal of Neuroscience

Année:

2001

Langue:

english

Fichier:

PDF, 465 KB

english, 2001

17

Cortico-hippocampal APP and NGF levels are dynamically altered by cholinergic muscarinic antagonist or M1 agonist treatment in normal mice

Hyemyung Seo, Andrew W. Ferree, Ole Isacson

Journal:

European Journal of Neuroscience

Année:

2002

Langue:

english

Fichier:

PDF, 156 KB

english, 2002

18

Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons

Sangmi Chung, Kai-C. Sonntag, Therese Andersson, Lars M. Bjorklund, Jae-Joon Park, Dong-Wook Kim, Un Jung Kang, Ole Isacson, Kwang-Soo Kim

Journal:

European Journal of Neuroscience

Année:

2002

Langue:

english

Fichier:

PDF, 705 KB

english, 2002

19

Orphan nuclear receptor Nurr1 directly transactivates the promoter activity of the tyrosine hydroxylase gene in a cell-specific manner

Kwang-Soo Kim, Chun-Hyung Kim, Dong-Youn Hwang, Hyemyung Seo, Sangmi Chung, Seok Jong Hong, Jin-Kyu Lim, Therese Anderson, Ole Isacson

Journal:

Journal of Neurochemistry

Année:

2003

Langue:

english

Fichier:

PDF, 204 KB

english, 2003

20

CD15, CD24, and CD29 Define a Surface Biomarker Code for Neural Lineage Differentiation of Stem Cells

Jan Pruszak, Wesley Ludwig, Alexandra Blak, Kambiz Alavian, Ole Isacson

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 1.54 MB

english, 2009

21

Development of Histocompatible Primate-Induced Pluripotent Stem Cells for Neural Transplantation

Michela Deleidi, Gunnar Hargus, Penelope Hallett, Teresia Osborn, Ole Isacson

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 4.54 MB

english, 2011

22

Herpesvirus-mediated gene delivery into the rat brain: specificity and efficiency of the neuron-specific enolase promoter

Julie K. Andersen, David M. Frim, Ole Isacson, Xandra O. Breakefield

Journal:

Cellular and Molecular Neurobiology

Année:

1993

Langue:

english

Fichier:

PDF, 1.57 MB

english, 1993

23

Lack of functional relevance of isolated cell damage in transplants of Parkinson’s disease patients

Oliver Cooper, Arnar Astradsson, Penny Hallett, Harold Robertson, Ivar Mendez, Ole Isacson

Journal:

Journal of Neurology

Année:

2009

Langue:

english

Fichier:

PDF, 367 KB

english, 2009

24

Functions of the nigrostriatal dopaminergic synapse and the use of neurotransplantation in Parkinson’s disease

Alex Tsui, Ole Isacson

Journal:

Journal of Neurology

Année:

2011

Langue:

english

Fichier:

PDF, 218 KB

english, 2011

25

Temporally induced Nurr1 can induce a non-neuronal dopaminergic cell type in embryonic stem cell differentiation

Kai-Christian Sonntag, Rabi Simantov, Kwang-Soo Kim, Ole Isacson

Journal:

European Journal of Neuroscience

Année:

2004

Langue:

english

Fichier:

PDF, 609 KB

english, 2004

26

Transplanted dopamine neurons derived from primate ES cells preferentially innervate DARPP-32 striatal progenitors within the graft

Daniela Ferrari, Rosario Sanchez-Pernaute, Hyojin Lee, Lorenz Studer, Ole Isacson

Journal:

European Journal of Neuroscience

Année:

2006

Langue:

english

Fichier:

PDF, 3.09 MB

english, 2006

27

REVIEW ARTILCE: Cell therapy and stem cells in animal models of motor neuron disorders

Eva Hedlund, Michael. P. Hefferan, Martin Marsala, Ole Isacson

Journal:

European Journal of Neuroscience

Année:

2007

Langue:

english

Fichier:

PDF, 353 KB

english, 2007

28

Genetic selection of sox1GFP-expressing neural precursors removes residual tumorigenic pluripotent stem cells and attenuates tumor formation after transplantation

S. Chung, B.-S. Shin, E. Hedlund, J. Pruszak, A. Ferree, Un Jung Kang, Ole Isacson, Kwang-Soo Kim

Journal:

Journal of Neurochemistry

Année:

2006

Langue:

english

Fichier:

PDF, 1.28 MB

english, 2006

29

Neural precursors derived from human embryonic stem cells maintain long-term proliferation without losing the potential to differentiate into all three neural lineages, including dopaminergic neurons

Sunghoi Hong, Un Jung Kang, Ole Isacson, Kwang-Soo Kim

Journal:

Journal of Neurochemistry

Année:

2008

Langue:

english

Fichier:

PDF, 794 KB

english, 2008

30

The hAPP-YAC transgenic model has elevated UPS activity in the frontal cortex similar to Alzheimer’s disease and Down’s syndrome

Hyemyung Seo, Ole Isacson

Journal:

Journal of Neurochemistry

Année:

2010

Langue:

english

Fichier:

PDF, 298 KB

english, 2010

31

Combined PET/MRS brain studies show dynamic and long-term physiological changes in a primate model of Parkinson disease

Brownell, Anna-Liisa, Jenkins, Bruce G., Elmaleh, David R., Deacon, Terrence W., Spealman, Roger D., Isacson, Ole

Journal:

Nature Medicine

Année:

1998

Langue:

english

Fichier:

PDF, 208 KB

english, 1998

32

OPINION: Failure of the ubiquitin–proteasome system in Parkinson's disease

McNaught, Kevin St P., Olanow, C. Warren, Halliwell, Barry, Isacson, Ole, Jenner, Peter

Journal:

Nature Reviews Neuroscience

Année:

2001

Langue:

english

Fichier:

PDF, 254 KB

english, 2001

33

10.1038/88362

Isacson, Ole, Bjorklund, Lars, Pernaute, Rosario Sanchez

Journal:

Nature Neuroscience

Année:

2001

Langue:

english

Fichier:

PDF, 509 KB

english, 2001

34

Neuronal xenotransplantation in Parkinson's disease

Schumacher, James M., Isacson, Ole

Journal:

Nature Medicine

Année:

1997

Fichier:

PDF, 246 KB

1997

35

Being too inclusive about synuclein inclusions

Isacson, Ole, Mendez, Ivar

Journal:

Nature Medicine

Année:

2010

Langue:

english

Fichier:

PDF, 97 KB

english, 2010

36

Benefits and risks of hosting animal cells in the human brain

Isacson, Ole, Breakefield, Xandra O.

Journal:

Nature Medicine

Année:

1997

Fichier:

PDF, 1.34 MB

1997

37

Transplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial and axonal fibres

Isacson, Ole, Deacon, Terrence W., Pakzaban, Peyman, Galpern, Wendy R., Dinsmore, Jonathan, Burns, Lindsay H.

Journal:

Nature Medicine

Année:

1995

Fichier:

PDF, 964 KB

1995

38

Analysis of Different Promoter Systems for Efficient Transgene Expression in Mouse Embryonic Stem Cell Lines

Sangmi Chung, Therese Andersson, Kai-C. Sonntag, Lars Björklund, Ole Isacson, Kwang-Soo Kim

Journal:

Année:

2002

Langue:

english

Fichier:

PDF, 252 KB

english, 2002

39

Long-Term Survival of Dopamine Neurons Derived from Parthenogenetic Primate Embryonic Stem Cells (Cyno-1) After Transplantation

Rosario Sánchez-Pernaute, Lorenz Studer, Daniela Ferrari, Anselme Perrier, Hyojin Lee, Angel Viñuela, Ole Isacson

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 406 KB

english, 2005

40

Stromal Cell–Derived Inducing Activity, Nurr1, and Signaling Molecules Synergistically Induce Dopaminergic Neurons from Mouse Embryonic Stem Cells

Dong-Wook Kim, Sangmi Chung, Mikyeong Hwang, Andrew Ferree, Hsing-Chen Tsai, Jae-Joon Park, Seungsoo Chung, Taick Sang Nam, Un Jung Kang, Ole Isacson, Kwang-Soo Kim

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 794 KB

english, 2006

41

Specific MicroRNAs Modulate Embryonic Stem Cell–Derived Neurogenesis

Anna M. Krichevsky, Kai-C. Sonntag, Ole Isacson, Kenneth S. Kosik

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 574 KB

english, 2006

42

Neural Precursors Derived from Embryonic Stem Cells, but Not Those from Fetal Ventral Mesencephalon, Maintain the Potential to Differentiate into Dopaminergic Neurons After Expansion In Vitro

Sangmi Chung, Byoung-Soo Shin, Michelle Hwang, Thomas Lardaro, Un Jung Kang, Ole Isacson, Kwang-Soo Kim

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 1.40 MB

english, 2006

43

Enhanced Yield of Neuroepithelial Precursors and Midbrain-Like Dopaminergic Neurons from Human Embryonic Stem Cells Using the Bone Morphogenic Protein Antagonist Noggin

Kai-Christian Sonntag, Jan Pruszak, Takahito Yoshizaki, Joris van Arensbergen, Rosario Sanchez-Pernaute, Ole Isacson

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 1.30 MB

english, 2007

44

Markers and Methods for Cell Sorting of Human Embryonic Stem Cell-Derived Neural Cell Populations

Jan Pruszak, Kai-Christian Sonntag, Moe Hein Aung, Rosario Sanchez-Pernaute, Ole Isacson

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 4.25 MB

english, 2007

45

Immature and Neurally Differentiated Mouse Embryonic Stem Cells Do Not Express a Functional Fas/Fas Ligand System

Gabriella Brunlid, Jan Pruszak, Benjamin Holmes, Ole Isacson, Kai-Christian Sonntag

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 780 KB

english, 2007

46

Fate Mapping and Lineage Analyses Demonstrate the Production of a Large Number of Striatal Neuroblasts After Transforming Growth Factor α and Noggin Striatal Infusions into the Dopamine-Depleted Striatum

Antoine de Chevigny, Oliver Cooper, Angel Vinuela, Casper Reske-Nielsen, Diane C. Lagace, Amelia J. Eisch, Ole Isacson

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 5.31 MB

english, 2008

47

In vivo evidence of D3 dopamine receptor sensitization in parkinsonian primates and rodents with l-DOPA-induced dyskinesias

Rosario Sánchez-Pernaute, Bruce G. Jenkins, Ji-Kyung Choi, Yin-Ching Iris Chen, Ole Isacson

Journal:

Neurobiology of Disease

Année:

2007

Langue:

english

Fichier:

PDF, 794 KB

english, 2007

48

Nociceptin/orphanin FQ receptor blockade attenuates MPTP-induced parkinsonism

Riccardo Viaro, Rosario Sanchez-Pernaute, Matteo Marti, Claudio Trapella, Ole Isacson, Michele Morari

Journal:

Neurobiology of Disease

Année:

2008

Langue:

english

Fichier:

PDF, 914 KB

english, 2008

49

The blood–brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates—Evidence from in vivo neuroimaging studies

Arnar Astradsson, Bruce G. Jenkins, Ji-Kyung Choi, Penelope J. Hallett, Michele A. Levesque, Jack S. McDowell, Anna-Liisa Brownell, Roger D. Spealman, Ole Isacson

Journal:

Neurobiology of Disease

Année:

2009

Langue:

english

Fichier:

PDF, 898 KB

english, 2009

50

Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits

Penelope J. Hallett, Jesse R. McLean, Andrew Kartunen, J. William Langston, Ole Isacson

Journal:

Neurobiology of Disease

Année:

2012

Langue:

english

Fichier:

PDF, 1.51 MB

english, 2012